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Most patients report a noticeable reduction within 2 weeks of the first dose, with significant quieting by weeks 4-6 as the dose titrates up

That said, I believe that for people with blood sugar concerns and metabolic issues, that the lowest dose possible to help with their blood markers may be great for them, Van Eck added

What rarely gets explained is why any of this matters beyond digestion

The decrease in GLP-1 and IL-22 levels in HFD-fed mice is consistent with our analysis of the GSE datasets, which showed decreased expression of GCG and IL-22-related genes in patients with diabetes compared to non-diabetic patients with obesity